Slc30a7^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Slc30a7^tm1Lex
• Name: solute carrier family 30 (zinc transporter), member 7; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5897132
• Synonyms: ZnT7 KO
• Gene: Slc30a7 Location: Chr3:115732622-115801055 bp, - strand Genetic Position: Chr3, 50.16 cM, cytoband G2
• Alliance: Slc30a7^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240760
• Parent Cell Line: Lex-2 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding sequence of exons 1 (from bp 11) and 2 (up to bp 10) was replaced with a lacZ gene and a neomycin resistance gene cassette. This creates a combined knock-out and reporter allele. (J:240760)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc30a7 Mutation: 21 strains or lines available

References

• Original: J:240760 Syring KE, et al., Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion. Endocrinology. 2016 Dec;157(12):4534-4541
• All: 1 reference(s)