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Mysm1tm1b(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Mysm1tm1b(KOMP)Wtsi
Name: myb-like, SWIRM and MPN domains 1; targeted mutation 1b, Wellcome Trust Sanger Institute
MGI ID: MGI:5896989
Synonyms: Mysm1tm1a(deltaMP)Wtsi
Gene: Mysm1  Location: Chr4:94942040-94979100 bp, - strand  Genetic Position: Chr4, 43.34 cM
Mutation
origin
Mutant Cell Line:  EPD0019_1_A04
Germline Transmission:  Earliest citation of germline transmission: J:179287
Parent Cell Line:  JM8 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_st0
 
Mutation detailsThe L1L2_st0 cassette was inserted at position 94973448 of Chromosome 4 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 94972656. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s). (J:179287)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mysm1 Mutation:  28 strains or lines available
References
Original:  J:179287 Jiang XX, et al., Control of B Cell Development by the Histone H2A Deubiquitinase MYSM1. Immunity. 2011 Dec 23;35(6):883-96
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory