Nox4^tm1.2Hwsc
Targeted Allele Detail

Summary

• Symbol: Nox4^tm1.2Hwsc
• Name: NADPH oxidase 4; targeted mutation 1.2, Harald H H W Schmidt
• MGI ID: MGI:5896730
• Synonyms: floxedNox4
• Gene: Nox4 Location: Chr7:86895304-87047918 bp, + strand Genetic Position: Chr7, 48.96 cM
• Alliance: Nox4^tm1.2Hwsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166948
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 14, and a neo cassette flanked by two loxP sites was inserted downstream of exon 15. The loxP-flanked neo cassette was removed by transient Cre-recombinase induced recombination, leaving loxP sites flanking exons 14-15.. (J:166948)

Generation of the Nox4^tm1.1Hwsc and Nox4^tm1.2Hwsc alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Nox4 Mutation: 70 strains or lines available

References

• Original: J:166948 Kleinschnitz C, et al., Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biol. 2010;8(9)
• All: 4 reference(s)