Sptlc1^tm1.1Rlp
Targeted Allele Detail

Summary

• Symbol: Sptlc1^tm1.1Rlp
• Name: serine palmitoyltransferase, long chain base subunit 1; targeted mutation 1.1, Richard L Proia
• MGI ID: MGI:5896526
• Synonyms: Stplc1^fl
• Gene: Sptlc1 Location: Chr13:53486784-53531433 bp, - strand Genetic Position: Chr13, 27.68 cM
• Alliance: Sptlc1^tm1.1Rlp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240861
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette flanked by both FRT and loxP sites was inserted upstream of exon 4 and a third loxP site downstream of exon 5. The neo cassette was excised in the germline by flp recombinase. (J:240861)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sptlc1 Mutation: 26 strains or lines available

References

• Original: J:240861 Alexaki A, et al., De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis. J Biol Chem. 2017 Mar 03;292(9):3929-3939
• All: 2 reference(s)