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Fgf4tm1.2Lwd
Targeted Allele Detail
Nomenclature
Symbol: Fgf4tm1.2Lwd
Name: fibroblast growth factor 4; targeted mutation 1.2, Mark Lewandoski
MGI ID: MGI:5888998
Synonyms: Fgf4delta
Gene: Fgf4  Location: Chr7:144847367-144865243 bp, + strand  Genetic Position: Chr7, 88.88 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:229949
Parent Cell Line:  v6.4 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA targeting vector is used to insert a loxP site and an FRT-site flanked PGK-NEO cassette into intron 1 followed by a second loxP site downstream of exon 3. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 2 and 3 floxed. Cre-mediated recombination removed the exons 2 and 3. (J:229949)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf4 Mutation:  20 strains or lines available
References
Original:  J:229949 Anderson MJ, et al., Fgf3-Fgf4-cis: A new mouse line for studying Fgf functions during mouse development. Genesis. 2016 Feb;54(2):91-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/28/2017
MGI 6.11
The Jackson Laboratory