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Dusp5tm1d(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Dusp5tm1d(KOMP)Wtsi
Name: dual specificity phosphatase 5; targeted mutation 1d, Wellcome Trust Sanger Institute
MGI ID: MGI:5888995
Synonyms: Dusp5-(Exc)
Gene: Dusp5  Location: Chr19:53529145-53541809 bp, + strand  Genetic Position: Chr19, 47.98 cM
Mutation
origin
Mutant Cell Line:  EPD0575_3_B05
Germline Transmission:  Earliest citation of germline transmission: J:240637
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 53533382 of Chromosome 19 upstream of exon 2 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 2 at position 53534246. The critical exon 2 is thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked exon 2. (J:240637)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dusp5 Mutation:  6 strains or lines available
References
Original:  J:240637 Kutty RG, et al., Dual Specificity Phosphatase 5 Is Essential for T Cell Survival. PLoS One. 2016;11(12):e0167246
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory