Map3k13^tm1Djz
Targeted Allele Detail

Summary

• Symbol: Map3k13^tm1Djz
• Name: mitogen-activated protein kinase kinase kinase 13; targeted mutation 1, Donald J Zack
• MGI ID: MGI:5888730
• Synonyms: Lzk^-, Lzk KO
• Gene: Map3k13 Location: Chr16:21643923-21752189 bp, + strand Genetic Position: Chr16, 12.92 cM
• Alliance: Map3k13^tm1Djz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255971
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Knockout mice were generated at Ingenious Targeting Laboratory by electroporating a targeting construct obtained from the KOMP repository. An FRT-flanked gene trap vector was inserted into intron 1 and loxP sites flanked exon 2. A capillary-based immunoassay demonstrated the absence of MAP3K13 expression in retinal ganglion cells (RGCs) isolated from homozygous mutant mice at 24 hrs after immunopanning injury. (J:255971)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k13 Mutation: 52 strains or lines available

References

• Original: J:255971 Welsbie DS, et al., Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. Neuron. 2017 Jun 21;94(6):1142-1154.e6
• All: 1 reference(s)