Sufu^tm2Rto
Targeted Allele Detail

Summary

• Symbol: Sufu^tm2Rto
• Name: SUFU negative regulator of hedgehog signaling; targeted mutation 2, Rune Toftgard
• MGI ID: MGI:5888725
• Synonyms: Sufu^{neo(frt)Ex456(fl)}
• Gene: Sufu Location: Chr19:46385335-46477243 bp, + strand Genetic Position: Chr19, 38.85 cM
• Alliance: Sufu^tm2Rto page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:248771
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 4 through 6 flanked by loxP sites, which by itself causes aberrant mRNA splicing and reduction of wild-type protein. (J:248771)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sufu Mutation: 59 strains or lines available

References

• Original: J:248771 Hoelzl MA, et al., Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model. Dev Biol. 2017 Sep 1;429(1):132-146
• All: 1 reference(s)