Smyd2^{tm1b(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Smyd2^{tm1b(KOMP)Wtsi}
• Name: SET and MYND domain containing 2; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:5883839
• Synonyms: Smyd2^-
• Gene: Smyd2 Location: Chr1:189612689-189654560 bp, - strand Genetic Position: Chr1, 95.03 cM, cytoband H6
• Alliance: Smyd2^{tm1b(KOMP)Wtsi} page
• IMPC: Smyd2 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232399
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Intragenic deletion
• Mutation details: The L1L2_gt2 cassette was inserted at position 189641827 of Chromosome 1 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 189642549. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s). (J:232399)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smyd2 Mutation: 140 strains or lines available

References

• Original: J:232399 Reynoird N, et al., Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer. Genes Dev. 2016 Apr 1;30(7):772-85
• All: 1 reference(s)