Smyd2^{tm1d(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Smyd2^{tm1d(KOMP)Wtsi}
• Name: SET and MYND domain containing 2; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:5883838
• Synonyms: Smyd2^-
• Gene: Smyd2 Location: Chr1:189612689-189654560 bp, - strand Genetic Position: Chr1, 95.03 cM, cytoband H6
• Alliance: Smyd2^{tm1d(KOMP)Wtsi} page
• IMPC: Smyd2 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240508
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The L1L2_gt2 cassette was inserted at position 189641827 of Chromosome 1 upstream of the critical exon 2 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of exon 2 at position 189642549. Exon 2 thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked exon 2. (J:240508)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smyd2 Mutation: 140 strains or lines available

References

• Original: J:240508 Bagislar S, et al., Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis. Oncotarget. 2016 Oct 11;7(41):66398-66415
• All: 1 reference(s)