Mgll^tm1.1Crv
Targeted Allele Detail

Summary

• Symbol: Mgll^tm1.1Crv
• Name: monoglyceride lipase; targeted mutation 1.1, Benjamin F Cravatt
• MGI ID: MGI:5883232
• Synonyms: MAGL^loxP, Mgll^loxP
• Gene: Mgll Location: Chr6:88701397-88805342 bp, + strand Genetic Position: Chr6, 39.51 cM
• Alliance: Mgll^tm1.1Crv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240386
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 3 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 4. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with a floxed exon 4. This exon codes for the catalytic Ser122 residue. (J:240386)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mgll Mutation: 30 strains or lines available

References

• Original: J:240386 Viader A, et al., Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action. Cell Rep. 2015 Aug 04;12(5):798-808
• All: 7 reference(s)