Setd7^tm1.2Faro
Targeted Allele Detail

Summary

• Symbol: Setd7^tm1.2Faro
• Name: SET domain containing (lysine methyltransferase) 7; targeted mutation 1.2, Fabio M V Rossi
• MGI ID: MGI:5883139
• Gene: Setd7 Location: Chr3:51422740-51468300 bp, - strand Genetic Position: Chr3, 22.5 cM
• Alliance: Setd7^tm1.2Faro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240314
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT site flanked neomycin resistance gene cassette and a loxP site were inserted into intron 4. A second loxP site was inserted into intron 8. The neo cassette was removed through subsquent flp-mediated recombination. The targeted exons were deleted through cre-mediated recombination. This creates a null allele with exons 5a through 8, encompassing all the exons encoding the catalytic domain, deleted. The inclusion of exon 5a in the deletion means that this allele affects both the short splice variant, which ends with exon 5a, and the long variant. (J:240314)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Setd7 Mutation: 29 strains or lines available

References

• Original: J:240314 Lehnertz B, et al., p53-dependent transcription and tumor suppression are not affected in Set7/9-deficient mice. Mol Cell. 2011 Aug 19;43(4):673-80
• All: 1 reference(s)