Setd7^tm1.1Faro
Targeted Allele Detail

Summary

• Symbol: Setd7^tm1.1Faro
• Name: SET domain containing (lysine methyltransferase) 7; targeted mutation 1.1, Fabio M V Rossi
• MGI ID: MGI:5883136
• Synonyms: Set7/9^fl
• Gene: Setd7 Location: Chr3:51422740-51468300 bp, - strand Genetic Position: Chr3, 22.5 cM
• Alliance: Setd7^tm1.1Faro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240314
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT site flanked neomycin resistance gene cassette and a loxP site were inserted into intron 4. A second loxP site was inserted into intron 8. The neo cassette was removed through subsquent flp-mediated recombination. This leaves a conditional-ready allele with exons 5a through 8 floxed, encompassing all the exons encoding the catalytic domain. (J:240314)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Setd7 Mutation: 29 strains or lines available

References

• Original: J:240314 Lehnertz B, et al., p53-dependent transcription and tumor suppression are not affected in Set7/9-deficient mice. Mol Cell. 2011 Aug 19;43(4):673-80
• All: 4 reference(s)