Tg(PGK1-Gnas*R201C)60Pabi
Transgene Detail

Summary

• Symbol: Tg(PGK1-Gnas*R201C)60Pabi
• Name: transgene lentiviral insertion 60, Paolo Bianco
• MGI ID: MGI:5883014
• Synonyms: PGK-Gsalpha^R201C
• Transgene: Tg(PGK1-Gnas*R201C)60Pabi Location: unknown
• Alliance: Tg(PGK1-Gnas*R201C)60Pabi page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:240241
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PGK1-Gnas*R201C)60Pabi expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Gnas

• Mutation details: A lentiviral construct containing Gnas with an arginine to cysteine change at codon 201 (R201C) under the constitutive human phosphoglycerate kinase promoter were used to generate mice. and an EGFP under the CMV promoter were used to generate mice. No information is provided about EGFP expression. Two founders were established: 60 and 61. Line 60 is entered as a representative line. (J:240241)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:240241 Saggio I, et al., Constitutive expression of Gsalpha(R201C) in mice produces a heritable, direct replica of human fibrous dysplasia bone pathology and demonstrates its natural history. J Bone Miner Res. 2014 Nov;29(11):2357-68
• All: 1 reference(s)