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Transgene Detail
Symbol: Tg(tetO-Tgfbr1*,-EGFP)3Twc
Name: transgene insertion 3, Tony Wyss-Coray
MGI ID: MGI:5882736
Synonyms: tetO-Alk5Ctrl
Transgene: Tg(tetO-Tgfbr1*,-EGFP)3Twc  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Constitutively active, Inducible, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Tg(tetO-Tgfbr1*,-EGFP)3Twc expresses 1 gene
Mutation detailsThe transgene is designed with a bidirectional tetracycline operator between two cytomegalovirus (CMV) minimal promoters in opposite orientation. One CMV promoter drives expression of a hemagglutinin (HA)-tagged, modified rat transforming growth factor, beta receptor I gene, while the other drives expression of an enhanced green fluorescent protein sequence. Tgfbr1 is made constitutively active by the introduction of a T204D mutation. (J:213201)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:213201 He Y, et al., ALK5-dependent TGF-beta signaling is a major determinant of late-stage adult neurogenesis. Nat Neurosci. 2014 Jul;17(7):943-52
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory