Senp1^tm1.1Eyeh
Targeted Allele Detail

Summary

• Symbol: Senp1^tm1.1Eyeh
• Name: SUMO1/sentrin specific peptidase 1; targeted mutation 1.1, Edward Yeh
• MGI ID: MGI:5882691
• Synonyms: Senp1^fl
• Gene: Senp1 Location: Chr15:97936625-97991625 bp, - strand Genetic Position: Chr15, 54.04 cM
• Alliance: Senp1^tm1.1Eyeh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226392
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: Exons 14 and 15 were floxed. Flp-mediated recombination removed the neomycin resistance selection cassette. (J:226392)

Generation of the Senp1^tm1.1Eyeh allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Senp1 Mutation: 65 strains or lines available

References

• Original: J:226392 Ferdaoussi M, et al., Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional beta cells. J Clin Invest. 2015 Oct 1;125(10):3847-60
• All: 8 reference(s)