Tbk1^tm1.1Holi
Targeted Allele Detail

Summary

• Symbol: Tbk1^tm1.1Holi
• Name: TANK-binding kinase 1; targeted mutation 1.1, Hongliang Li
• MGI ID: MGI:5882564
• Synonyms: Tbk1^flox
• Gene: Tbk1 Location: Chr10:121382360-121422692 bp, - strand Genetic Position: Chr10, 69.84 cM
• Alliance: Tbk1^tm1.1Holi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239911
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT site flanked neomycin resistance gene cassette and a second loxP site were inserted into intron 1. The neo cassette was removed through subsequent FLP-mediated recombination, leaving a conditional-ready allele with a floxed exon 1. (J:239911)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbk1 Mutation: 57 strains or lines available

References

• Original: J:239911 Deng KQ, et al., Suppressor of IKKvarepsilon is an essential negative regulator of pathological cardiac hypertrophy. Nat Commun. 2016 Jun 01;7:11432
• All: 1 reference(s)