Repin1^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Repin1^tm1.1Arte
• Name: replication initiator 1; targeted mutation 1.1 TaconicArtemis
• MGI ID: MGI:5882541
• Synonyms: Rep1^flox
• Gene: Repin1 Location: Chr6:48570817-48576016 bp, + strand Genetic Position: Chr6, 23.57 cM
• Alliance: Repin1^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229864
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites, and two frt- or F3-flanked positive selection markers that were used in order to increase co-recombination frequency of both loxP sites were removed by Flp-mediated recombination. (J:229864)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Repin1 Mutation: 46 strains or lines available

References

• Original: J:229864 Kern M, et al., Liver-restricted Repin1 deficiency improves whole-body insulin sensitivity, alters lipid metabolism, and causes secondary changes in adipose tissue in mice. Diabetes. 2014 Oct;63(10):3295-309
• All: 2 reference(s)