Aspm^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Aspm^{tm1c(KOMP)Wtsi}
• Name: abnormal spindle microtubule assembly; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5882419
• Synonyms: Aspm^f
• Gene: Aspm Location: Chr1:139382510-139421829 bp, + strand Genetic Position: Chr1, 61.45 cM, cytoband F
• Alliance: Aspm^{tm1c(KOMP)Wtsi} page
• IMPC: Aspm gene page

Mutation origin

• Mutant Cell Line: EPD0320_1_A06
• Germline Transmission: Earliest citation of germline transmission: J:226691
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_gt1
• Mutation details: The L1L2_gt1 cassette was inserted at position 139391526 of Chromosome 1 upstream of exon 7 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of exon 7 at position 139392331. A "conditional ready" (floxed) allele is created by flp recombinase expression in mice, removing the lacZ sequences and neomycin selection cassette and leaving exon 7 flanked by loxP sites. (J:226691)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aspm Mutation: 138 strains or lines available

References

• Original: J:226691 Williams SE, et al., Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice. Development. 2015 Nov 15;142(22):3921-32
• All: 1 reference(s)