Fcamr^tm1.1Jsv
Targeted Allele Detail

Summary

• Symbol: Fcamr^tm1.1Jsv
• Name: Fc receptor, IgA, IgM, high affinity; targeted mutation 1.1, J Sjef Verbeek
• MGI ID: MGI:5882402
• Synonyms: FcalphamuR^fl, FcamR (4D6)- Floxed, Fcamr^tm1.1Sjv
• Gene: Fcamr Location: Chr1:130728639-130742477 bp, + strand Genetic Position: Chr1, 56.89 cM, cytoband F
• Alliance: Fcamr^tm1.1Jsv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240097
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: This allele was derived from Fcamr^tm1Sjv by flp recombinase-mediated deletion of a FRT site-flanked neomycin selection cassette from intron 3, leaving a loxP site and a FRT site in intron 3 and a second loxP site in intron 4. Quantitative reverse transcription-PCR (qRT-PCR) analysis of total kidney RNA demonstrated approximately equal transcript levels in tissue from mice homozygous for the floxed allele vs. wild-type mice. (J:240097)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fcamr Mutation: 41 strains or lines available

References

• Original: J:240097 Legrain S, et al., Involvement of Fcalpha/mu Receptor in IgM Anti-Platelet, but Not Anti-Red Blood Cell Autoantibody Pathogenicity in Mice. J Immunol. 2015 Nov 01;195(9):4171-5
• All: 2 reference(s)