Fcamr^tm1.2Jsv
Targeted Allele Detail

Summary

• Symbol: Fcamr^tm1.2Jsv
• Name: Fc receptor, IgA, IgM, high affinity; targeted mutation 1.2, J Sjef Verbeek
• MGI ID: MGI:5882398
• Synonyms: Fcalpha/muR KO, FcamR (4D6)- Null, Fcamr^tm1.2Sjv
• Gene: Fcamr Location: Chr1:130728639-130742477 bp, + strand Genetic Position: Chr1, 56.89 cM, cytoband F
• Alliance: Fcamr^tm1.2Jsv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240097
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele was derived from Fcamr^tm1Sjv by Cre recombinase-mediated deletion of a loxP-flanked DNA segment containing exon 4 and a FRT site-flanked selection cassette. Quantitative reverse transcription-PCR (qRT-PCR) analysis of total kidney RNA from homozygous mutant vs. wild-type mice demonstrated that the mutant RNA is present at ~45% of the wild-type level. These mice express a soluble form of the receptor that does not compete effectively in vitro with the native, membrane-bound receptor for binding to IgM monoclonal antibody. (J:240097)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fcamr Mutation: 41 strains or lines available

References

• Original: J:240097 Legrain S, et al., Involvement of Fcalpha/mu Receptor in IgM Anti-Platelet, but Not Anti-Red Blood Cell Autoantibody Pathogenicity in Mice. J Immunol. 2015 Nov 01;195(9):4171-5
• All: 1 reference(s)