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Targeted Allele Detail
Symbol: Fcamrtm1Jsv
Name: Fc receptor, IgA, IgM, high affinity; targeted mutation 1, J Sjef Verbeek
MGI ID: MGI:5882394
Synonyms: FcamR (4D6), Fcamrtm1Sjv
Gene: Fcamr  Location: Chr1:130800902-130814740 bp, + strand  Genetic Position: Chr1, 56.89 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:240097
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
Mutation detailsA loxP site followed by a FRT site-flanked, inverted neomycin selection cassette have been inserted into intron 3 and a single loxP site has been introduced into intron 4. Quantitative reverse transcription-PCR (qRT-PCR) analysis of total kidney RNA from homozygous mutant vs. wild-type mice demonstrated that this allele is hypomorphic, its transcript present at only ~1.5% of the wild-type level. (J:240097)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fcamr Mutation:  34 strains or lines available
Original:  J:240097 Legrain S, et al., Involvement of Fcalpha/mu Receptor in IgM Anti-Platelet, but Not Anti-Red Blood Cell Autoantibody Pathogenicity in Mice. J Immunol. 2015 Nov 01;195(9):4171-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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