Fcamr^tm1Jsv
Targeted Allele Detail

Summary

• Symbol: Fcamr^tm1Jsv
• Name: Fc receptor, IgA, IgM, high affinity; targeted mutation 1, J Sjef Verbeek
• MGI ID: MGI:5882394
• Synonyms: FcamR (4D6), Fcamr^tm1Sjv
• Gene: Fcamr Location: Chr1:130728639-130742477 bp, + strand Genetic Position: Chr1, 56.89 cM, cytoband F
• Alliance: Fcamr^tm1Jsv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240097
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A loxP site followed by a FRT site-flanked, inverted neomycin selection cassette have been inserted into intron 3 and a single loxP site has been introduced into intron 4. Quantitative reverse transcription-PCR (qRT-PCR) analysis of total kidney RNA from homozygous mutant vs. wild-type mice demonstrated that this allele is hypomorphic, its transcript present at only ~1.5% of the wild-type level. (J:240097)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fcamr Mutation: 41 strains or lines available

References

• Original: J:240097 Legrain S, et al., Involvement of Fcalpha/mu Receptor in IgM Anti-Platelet, but Not Anti-Red Blood Cell Autoantibody Pathogenicity in Mice. J Immunol. 2015 Nov 01;195(9):4171-5
• All: 1 reference(s)