Casp1^tm1Gne
Targeted Allele Detail

Summary

• Symbol: Casp1^tm1Gne
• Name: caspase 1; targeted mutation 1, Genentech
• MGI ID: MGI:5882087
• Gene: Casp1 Location: Chr9:5298517-5307281 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Casp1^tm1Gne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226780
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exons 1 and 2 were deleted. (J:226780)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp1 Mutation: 41 strains or lines available

References

• Original: J:226780 Kayagaki N, et al., Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 2015 Oct 29;526(7575):666-71
• All: 12 reference(s)