Cav1^tm2Tt
Targeted Allele Detail

Summary

• Symbol: Cav1^tm2Tt
• Name: caveolin 1, caveolae protein; targeted mutation 2, Timothy C Thompson
• MGI ID: MGI:5882070
• Synonyms: Cav1^fl
• Gene: Cav1 Location: Chr6:17306387-17341323 bp, + strand Genetic Position: Chr6, 7.73 cM, cytoband A2
• Alliance: Cav1^tm2Tt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239597
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site flanked neomycin resistance gene cassette was inserted into intron 1 and a third loxP site into intron 2, creating a conditional-ready allele with a floxed exon 2. This allele was used to generate allele Cav1^tm1Tt. (J:82490)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cav1 Mutation: 33 strains or lines available

References

• Original: J:82490 Cao G, et al., Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis. Am J Pathol. 2003 Apr;162(4):1241-8
• All: 12 reference(s)