Foxf2^tm1.1Pca
Targeted Allele Detail

Summary

• Symbol: Foxf2^tm1.1Pca
• Name: forkhead box F2; targeted mutation 1.1, Peter Carlsson
• MGI ID: MGI:5829674
• Synonyms: Foxf2^fl
• Gene: Foxf2 Location: Chr13:31809799-31815386 bp, + strand Genetic Position: Chr13, 13.48 cM, cytoband A4
• Alliance: Foxf2^tm1.1Pca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239656
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a further loxP site and an FRT site flanked neomycin resistance gene cassette into intron 1. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with a floxed exon 1. (J:239656)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxf2 Mutation: 20 strains or lines available

References

• Original: J:239656 Reyahi A, et al., Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier. Dev Cell. 2015 Jul 06;34(1):19-32
• All: 5 reference(s)