Poglut1^tm1.1Hjnd
Targeted Allele Detail

Summary

• Symbol: Poglut1^tm1.1Hjnd
• Name: protein O-glucosyltransferase 1; targeted mutation 1.1, Hamed Jafar-Nejad
• MGI ID: MGI:5829562
• Synonyms: Rumi^flox
• Gene: Poglut1 Location: Chr16:38345499-38370620 bp, - strand Genetic Position: Chr16, 26.86 cM
• Alliance: Poglut1^tm1.1Hjnd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239275
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exons 2 and 3 floxed. (J:239275)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Poglut1 Mutation: 61 strains or lines available

References

• Original: J:239275 Thakurdas SM, et al., Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi). Hepatology. 2016 Feb;63(2):550-65
• All: 2 reference(s)