Mapk14^tm2Dvb
Targeted Allele Detail

Summary

• Symbol: Mapk14^tm2Dvb
• Name: mitogen-activated protein kinase 14; targeted mutation 2, Dmitry V Bulavin
• MGI ID: MGI:5829256
• Synonyms: p38^ki, p38^Y182F
• Gene: Mapk14 Location: Chr17:28910303-28967380 bp, + strand Genetic Position: Chr17, 14.85 cM
• Alliance: Mapk14^tm2Dvb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237913
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting vector was designed (by site-directed mutagenesis) to substitute a tyrosine to phenylalanine at amino acid position 182. (J:237913)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapk14 Mutation: 41 strains or lines available

References

• Original: J:237913 Brichkina A, et al., p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis. Genes Dev. 2016 Dec 01;30(23):2623-2636
• All: 1 reference(s)