Ocln^tm1.1Alpl
Targeted Allele Detail

Summary

• Symbol: Ocln^tm1.1Alpl
• Name: occludin; targeted mutation 1.1, Alexander Ploss
• MGI ID: MGI:5828874
• Synonyms: mOCLN/hEL2
• Gene: Ocln Location: Chr13:100633015-100689226 bp, - strand Genetic Position: Chr13, 53.23 cM
• Alliance: Ocln^tm1.1Alpl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239318
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEv

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: To create a hepatitis C virus uptake model, the part of exon 3 encoding extracellular loop 2 (EL2) was replaced with the equivalent part of exon 3 of the human orthologue. A loxP site flanked neomycin resistance gene cassette was inserted into human intron 3. This neo cassette was removed through subsequent cre-mediated recombination. (J:239318)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ocln Mutation: 31 strains or lines available

References

• Original: J:239318 Ding Q, et al., Mice Expressing Minimally Humanized CD81 and Occludin Genes Support Hepatitis C Virus Uptake In Vivo. J Virol. 2017 Feb 15;91(4):e01799-16
• All: 1 reference(s)