Cd81^tm1.1Alpl
Targeted Allele Detail

Summary

• Symbol: Cd81^tm1.1Alpl
• Name: CD81 antigen; targeted mutation 1.1, Alexander Ploss
• MGI ID: MGI:5828873
• Synonyms: mCD81/hEL2
• Gene: Cd81 Location: Chr7:142606487-142621667 bp, + strand Genetic Position: Chr7, 88.1 cM
• Alliance: Cd81^tm1.1Alpl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239318
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEv

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: To create a hepatitis C virus uptake model, exons 6 and 7, encoding extracellular loop 2 (EL2), were replaced with exons 6 and 7 of the human orthologue. A loxP site flanked neomycin resistance gene cassette was inserted into human intron 6. This neo cassette was removed through subsequent cre-mediated recombination. (J:239318)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd81 Mutation: 20 strains or lines available

References

• Original: J:239318 Ding Q, et al., Mice Expressing Minimally Humanized CD81 and Occludin Genes Support Hepatitis C Virus Uptake In Vivo. J Virol. 2017 Feb 15;91(4):e01799-16
• All: 1 reference(s)