Pdpn^tm2Bwd
Targeted Allele Detail

Summary

• Symbol: Pdpn^tm2Bwd
• Name: podoplanin; targeted mutation 2, Lynda F Bonewald
• MGI ID: MGI:5828525
• Synonyms: E11/gp38 flx
• Gene: Pdpn Location: Chr4:142994001-143026134 bp, - strand Genetic Position: Chr4, 77.29 cM
• Alliance: Pdpn^tm2Bwd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235238
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the coding sequence in exon 1. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 1. Authors state that this allele is hypomorphic because low levels of transcript are detected while no protein is detected. (J:235238)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdpn Mutation: 31 strains or lines available

References

• Original: J:235238 Prideaux M, et al., Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms. PLoS One. 2015;10(5):e0125731
• All: 1 reference(s)