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Rorbtm1.1(cre/ERT2)Ddg
Targeted Allele Detail
Nomenclature
Symbol: Rorbtm1.1(cre/ERT2)Ddg
Name: RAR-related orphan receptor beta; targeted mutation 1.1, David D Ginty
MGI ID: MGI:5828138
Synonyms: RorbetaCreERT2
Gene: Rorb  Location: Chr19:18930609-19111196 bp, - strand  Genetic Position: Chr19, 13.28 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:239228
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA Cre recombinase-estrogen receptor T2 (CreERT2) fusion-FRT-Neomycin-FRT-loxP cassette was introduced into the first coding ATG, replacing the last 4 bp of the exon 1. Homologous recombination was achieved in 129S6/SvEvTac-derived embryonic stem cells and resultant chimeric mice were crossed with Flp mice to excise the neomycin cassette, (J:239228)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Rorb     Summary of all recombinase alleles driven by Rorb.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rorb Mutation:  8 strains or lines available
References
Original:  J:239228 Abraira VE, et al., The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell. 2017 Jan 12;168(1-2):295-310.e19
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory