Rorbtm1.1(cre/ERT2)Ddg
Targeted Allele Detail
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Symbol: |
Rorbtm1.1(cre/ERT2)Ddg |
Name: |
RAR-related orphan receptor beta; targeted mutation 1.1, David D Ginty |
MGI ID: |
MGI:5828138 |
Synonyms: |
RorbetaCreERT2 |
Gene: |
Rorb Location: Chr19:18907969-19088560 bp, - strand Genetic Position: Chr19, 13.28 cM
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Alliance: |
Rorbtm1.1(cre/ERT2)Ddg page
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Germline Transmission: |
Earliest citation of germline transmission:
J:239228
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutations: |
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Insertion, Intragenic deletion
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Rorbtm1.1(cre/ERT2)Ddg expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: A Cre recombinase-estrogen receptor T2 (CreERT2) fusion-FRT-Neomycin-FRT-loxP cassette was introduced into the first coding ATG, replacing the last 4 bp of the exon 1. Homologous recombination was achieved in 129S6/SvEvTac-derived embryonic stem cells and resultant chimeric mice were crossed with Flp mice to excise the neomycin cassette,
(J:239228)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Rorb
(mouse)
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Original: |
J:239228 Abraira VE, et al., The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell. 2017 Jan 12;168(1-2):295-310.e19 |
All: |
3 reference(s) |
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