Erc2^tm1Ksak
Targeted Allele Detail

Summary

• Symbol: Erc2^tm1Ksak
• Name: ELKS/RAB6-interacting/CAST family member 2; targeted mutation 1, Kenji Sakimura
• MGI ID: MGI:5827585
• Synonyms: CAST-S45A, CAST^S45A
• Gene: Erc2 Location: Chr14:27344385-28200494 bp, + strand Genetic Position: Chr14, 16.51 cM
• Alliance: Erc2^tm1Ksak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238996
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: An FRT site flanked neomycin resistance gene cassette was inserted into intron 2. Exon 2 was targeted with a codon change: an S45A (TCT to GCC) mutation. This mutation creates a diagnostic MscI restriction site and changes serine 45 to an alanine, thus preventing phosphorylation of the peptide at that position. (J:238996)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erc2 Mutation: 112 strains or lines available

References

• Original: J:238996 Mochida S, et al., SAD-B Phosphorylation of CAST Controls Active Zone Vesicle Recycling for Synaptic Depression. Cell Rep. 2016 Sep 13;16(11):2901-13
• All: 1 reference(s)