Trex1^tm1.1Nyan
Targeted Allele Detail

Summary

• Symbol: Trex1^tm1.1Nyan
• Name: three prime repair exonuclease 1; targeted mutation 1.1, Nan Yan
• MGI ID: MGI:5827583
• Synonyms: TREX1-V235fs
• Gene: Trex1 Location: Chr9:108887000-108888791 bp, - strand Genetic Position: Chr9, 59.63 cM
• Alliance: Trex1^tm1.1Nyan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233654
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was floxed. A human cDNA containing the V235fs mutation was knocked in. This mutation creates a dominant frameshift mutation that truncates the C terminus and is associated with retinal vasculopathy with cerebral leukodystrophy. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:233654)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trex1 Mutation: 29 strains or lines available

References

• Original: J:233654 Hasan M, et al., Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation. Immunity. 2015 Sep 15;43(3):463-74
• All: 1 reference(s)