Rnf31tm2c(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Rnf31tm2c(KOMP)Wtsi |
Name: |
ring finger protein 31; targeted mutation 2c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5825498 |
Synonyms: |
Hoipflox |
Gene: |
Rnf31 Location: Chr14:55829199-55841131 bp, + strand Genetic Position: Chr14, 28.19 cM
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Alliance: |
Rnf31tm2c(KOMP)Wtsi page
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IMPC: |
Rnf31 gene page |
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Mutant Cell Line: |
EPD0161_5_A05 |
Germline Transmission: |
Earliest citation of germline transmission:
J:238820
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 55831290 of Chromosome 14 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 55834603. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
(J:238820)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rnf31 Mutation: |
49 strains or lines available
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Original: |
J:238820 Peltzer N, et al., HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death. Cell Rep. 2014 Oct 09;9(1):153-65 |
All: |
5 reference(s) |
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