Scn5a^tm2.1Tjh
Targeted Allele Detail

Summary

• Symbol: Scn5a^tm2.1Tjh
• Name: sodium channel, voltage-gated, type V, alpha; targeted mutation 2.1, Thomas J Hund
• MGI ID: MGI:5825295
• Synonyms: Scn5a S571A
• Gene: Scn5a Location: Chr9:119312474-119408082 bp, - strand Genetic Position: Chr9, 71.33 cM
• Alliance: Scn5a^tm2.1Tjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239053
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 13 was modified such that an S571A muatation was created in the translated peptide. LoxP sites were inserted in intron 9 and intron 13. An FRT site flanked neomycin resistance gene cassette was inserted between exon 13 and the loxP site. The neo cassette was removed through flp-mediated recombination. The substituted alanine can not be phosphorylated (whereas the original serine can). (J:239053)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn5a Mutation: 103 strains or lines available

References

• Original: J:239053 Glynn P, et al., Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo. Circulation. 2015 Aug 18;132(7):567-77
• All: 2 reference(s)