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Spp1tm1.1Dhd
Targeted Allele Detail
Nomenclature
Symbol: Spp1tm1.1Dhd
Name: secreted phosphoprotein 1; targeted mutation 1.1, Dick Heinegard
MGI ID: MGI:5825176
Synonyms: OPN-
Gene: Spp1  Location: Chr5:104435118-104441050 bp, + strand  Genetic Position: Chr5, 50.68 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:237104
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neomycin resistance cassette replaced exons 1 through 3. Cre-mediated recombination removed the selection cassette. Western blot analysis confirmed the absence of protein expression in the long bones. (J:237104)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spp1 Mutation:  16 strains or lines available
References
Original:  J:237104 Franzen A, et al., Altered osteoclast development and function in osteopontin deficient mice. J Orthop Res. 2008 May;26(5):721-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory