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Slc6a8tm1Lbar
Targeted Allele Detail
Nomenclature
Symbol: Slc6a8tm1Lbar
Name: solute carrier family 6 (neurotransmitter transporter, creatine), member 8; targeted mutation 1, Laura Baroncelli
MGI ID: MGI:5825017
Gene: Slc6a8  Location: ChrX:73673150-73682502 bp, + strand  Genetic Position: ChrX, 37.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:232606
Parent Cell Line:  A8 (ES Cell)
Strain of Origin:  (C57BL/6 x 129P2/OlaHsd)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThis KO first allele (reporter-tagged insertion with conditional potential) was generated using EUCOMM vector (PCS00081_A09). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exons. The critical exons 5 to 7 are thus flanked by loxP sites. For vector details, see Slc6a8tm1a(KOMP)Wtsi. (J:232606)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a8 Mutation:  6 strains or lines available
Notes
ES cells used for allele generation: clone A8, gift fromA. Wutz, Wellcome Trust Centre for Stem Cell Research, Stem Cell Institute, University of Cambridge (J:232606).
References
Original:  J:232606 Baroncelli L, et al., A novel mouse model of creatine transporter deficiency. F1000Res. 2014;3:228
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory