Cd300lf^tm1Jco
Targeted Allele Detail

Summary

• Symbol: Cd300lf^tm1Jco
• Name: CD300 molecule like family member F; targeted mutation 1, John E Coligan
• MGI ID: MGI:5824826
• Synonyms: Cd300f^-
• Gene: Cd300lf Location: Chr11:115007040-115024818 bp, - strand Genetic Position: Chr11, 80.59 cM
• Alliance: Cd300lf^tm1Jco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238440
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 1 and a FRT-flanked neomycin resistance gene cassette and a second loxP site into intron 3. The neo cassette and exons 2 and 3 were deleted through subsequent cre-mediated recombination, creating a null allele. Mice carying this allele develop SLE (systemic lupus erythematosus) like phenotypes. (J:238440)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd300lf Mutation: 23 strains or lines available

References

• Original: J:238440 Tian L, et al., Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice. Cell Death Differ. 2016 Jun;23(6):1086-96
• All: 6 reference(s)