Cd6^tm1Linf
Targeted Allele Detail

Summary

• Symbol: Cd6^tm1Linf
• Name: CD6 antigen; targeted mutation 1, Feng Lin
• MGI ID: MGI:5824697
• Gene: Cd6 Location: Chr19:10766705-10807422 bp, - strand Genetic Position: Chr19, 7.16 cM
• Alliance: Cd6^tm1Linf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238478
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5-7 have been replaced by a neomycin resistance cassette. Absence of CD6 protein in peripheral lymphocytes of homozygous mutant mice was confirmed by fluorescence-activated cell sorting (FACS) analysis. (J:238988)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd6 Mutation: 27 strains or lines available

References

• Original: J:238478 Enyindah-Asonye G, et al., CD6 Receptor Regulates Intestinal Ischemia/Reperfusion-induced Injury by Modulating Natural IgM-producing B1a Cell Self-renewal. J Biol Chem. 2017 Jan 13;292(2):661-671
• All: 4 reference(s)