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Transgene Detail
Symbol: Tg(Myh6-DsRed1*/COX8A)40830Rag
Name: transgene insertion 4083, Roberta Gottlieb
MGI ID: MGI:5824689
Synonyms: alpha-MCH-MitoTimer
Transgene: Tg(Myh6-DsRed1*/COX8A)40830Rag  Location: unknown  
Strain of Origin:  C57BL/6J
Transgene Type:    Transgenic (Reporter)
Mutation:    Insertion
Mutation detailsThe transgenic construct contains a murine Myh6 gene promoter directing expression of an a modified dsRed1 cDNA fused to the mitochondrial targeting sequence from human COX8A followed by a human growth hormone polyadenylation signal. Transgene expression is detected predominantly in the heart ventricles, with lower expression in the atria, which is expected due to the lower number of mitochondria in the atrial cardiomyocytes. The modified DsRed1-E5 (or Timer) fluorescent protein contains two amino acid substitutions, V105A and S197T, which increase fluorescence activity and allow a color shift from green to red over 48 hours. (J:238987)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:238987 Stotland A, et al., alpha-MHC MitoTimer mouse: In vivo mitochondrial turnover model reveals remarkable mitochondrial heterogeneity in the heart. J Mol Cell Cardiol. 2016 Jan;90:53-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory