Ppp6c^tm1.1Xya
Targeted Allele Detail

Summary

• Symbol: Ppp6c^tm1.1Xya
• Name: protein phosphatase 6, catalytic subunit; targeted mutation 1.1, Xiao Yang
• MGI ID: MGI:5824290
• Synonyms: Ppp6c^F
• Gene: Ppp6c Location: Chr2:39084381-39116361 bp, - strand Genetic Position: Chr2, 24.44 cM, cytoband B
• Alliance: Ppp6c^tm1.1Xya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233642
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into introns 1 and 4. An FRT site flanked neomycin resistance gene cassette was inserted into intron 4 downstream of the loxP site. The neo cassette was removed through flp-mediated recombination, leaving a conditional ready allele with floxed exons 2-4. (J:233642)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp6c Mutation: 39 strains or lines available

References

• Original: J:233642 Hu MW, et al., Loss of protein phosphatase 6 in oocytes causes failure of meiosis II exit and impaired female fertility. J Cell Sci. 2015 Oct 15;128(20):3769-80
• All: 4 reference(s)