Atp13a2^tm1.1Noha
Targeted Allele Detail

Summary

• Symbol: Atp13a2^tm1.1Noha
• Name: ATPase type 13A2; targeted mutation 1.1, Nobutaka Hattori
• MGI ID: MGI:5824140
• Synonyms: Atp13a2^flox
• Gene: Atp13a2 Location: Chr4:140714184-140734641 bp, + strand Genetic Position: Chr4, 73.29 cM
• Alliance: Atp13a2^tm1.1Noha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238740
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette and a further loxP site were inserted into intron 3. The neo cassette was removed through flp-mediated recombination, leaving a conditional ready allele with exons 2 and 3 floxed. (J:238740)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp13a2 Mutation: 59 strains or lines available

References

• Original: J:238740 Sato S, et al., Lysosomal Storage of Subunit c of Mitochondrial ATP Synthase in Brain-Specific Atp13a2-Deficient Mice. Am J Pathol. 2016 Dec;186(12):3074-3082
• All: 1 reference(s)