Ripk1^tm1.1Toml
Targeted Allele Detail

Summary

• Symbol: Ripk1^tm1.1Toml
• Name: receptor (TNFRSF)-interacting serine-threonine kinase 1; targeted mutation 1.1, Tom Luedde
• MGI ID: MGI:5823780
• Synonyms: Ripk1^FL
• Gene: Ripk1 Location: Chr13:34186346-34221130 bp, + strand Genetic Position: Chr13, 14.01 cM
• Alliance: Ripk1^tm1.1Toml page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238416
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 4 and 5 were flanked by loxP sites. An FRT site flanked double cassette of a beta galactosidase (lacZ) gene cassette and a neomycin resistance gene cassette, separated by a loxP site, was inserted into intron 3. The lacZ-neo double cassette was removed by subsequent flp-mediated recombination. Exons 4 and 5 remain floxed. (J:238416)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk1 Mutation: 32 strains or lines available

References

• Original: J:238416 Schneider AT, et al., RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer. Cancer Cell. 2017 Jan 09;31(1):94-109
• All: 4 reference(s)