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Targeted Allele Detail
Symbol: Pdx1tm1.1Cvw
Name: pancreatic and duodenal homeobox 1; targeted mutation 1.1, Christopher VE Wright
MGI ID: MGI:5823773
Synonyms: Pdx1deltaII
Gene: Pdx1  Location: Chr5:147206907-147212658 bp, + strand  Genetic Position: Chr5, 86.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:238418
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Intragenic deletion
Mutation detailsUsing the Pdx1tm1Mgn Loxed Cassette Acceptor allele as a starting point, the cassette was replaced with another cassette via cre recombination mediated cassette exchange. The replacement cassette is comprised of: forward lox71 site, an FRT site flanked hygromycin resistance gene cassette, the genomic sequence encompassing the cis-regulatory area IV, I and III regions and exon 1, and a reverse lox2272 site. After removal of the hygro cassette through flp-mediated recombination this leaves an allele with a deletion of 256 bp upstream of exon 1 wich includes the entire area II. (J:238418)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdx1 Mutation:  28 strains or lines available
Original:  J:238418 Yang YP, et al., The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine cell specification and postnatal beta-cell maturation. Development. 2017 Jan 15;144(2):248-257
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory