Aim2^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Aim2^tm1.1Arte
• Name: absent in melanoma 2; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5823429
• Synonyms: Aim2^flox
• Gene: Aim2 Location: Chr1:173178445-173293606 bp, + strand Genetic Position: Chr1, 80.33 cM
• Alliance: Aim2^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238323
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site upstream of exon 5, followed by a FRT-flanked puromycin resistance cassette downstream of exon 5 and another loxP site were inserted via homologous recombination. The puromycin resistance cassette was removed via Flp-mediated recombination leaving exon 5 flanked by loxP sites. (J:238323)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aim2 Mutation: 36 strains or lines available

References

• Original: J:238323 Jakobs C, et al., AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis. PLoS One. 2015;10(6):e0131702
• All: 2 reference(s)