Apbb1iptm1.2Fbg
Targeted Allele Detail
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Symbol: |
Apbb1iptm1.2Fbg |
Name: |
amyloid beta precursor protein binding family B member 1 interacting protein; targeted mutation 1.2, Frank B Gertler |
MGI ID: |
MGI:5823259 |
Synonyms: |
RIAM KO |
Gene: |
Apbb1ip Location: Chr2:22664106-22765665 bp, + strand Genetic Position: Chr2, 15.15 cM, cytoband A3
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Alliance: |
Apbb1iptm1.2Fbg page
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 3, and an FRT-flanked neomycin resistance (neo) cassette, followed by a second loxP site, downstream of exon 4. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 3 through 4 floxed. Subsequent Cre-mediated recombination resulted in the removal of exons 3 and 4 in the germline.
(J:229955)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Apbb1ip Mutation: |
42 strains or lines available
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Original: |
J:229955 Su W, et al., Rap1 and its effector RIAM are required for lymphocyte trafficking. Blood. 2015 Dec 17;126(25):2695-703 |
All: |
4 reference(s) |
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