Apbb1ip^tm1.2Fbg
Targeted Allele Detail

Summary

• Symbol: Apbb1ip^tm1.2Fbg
• Name: amyloid beta precursor protein binding family B member 1 interacting protein; targeted mutation 1.2, Frank B Gertler
• MGI ID: MGI:5823259
• Synonyms: RIAM KO
• Gene: Apbb1ip Location: Chr2:22664106-22765665 bp, + strand Genetic Position: Chr2, 15.15 cM, cytoband A3
• Alliance: Apbb1ip^tm1.2Fbg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229955
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 3, and an FRT-flanked neomycin resistance (neo) cassette, followed by a second loxP site, downstream of exon 4. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 3 through 4 floxed. Subsequent Cre-mediated recombination resulted in the removal of exons 3 and 4 in the germline. (J:229955)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apbb1ip Mutation: 43 strains or lines available

References

• Original: J:229955 Su W, et al., Rap1 and its effector RIAM are required for lymphocyte trafficking. Blood. 2015 Dec 17;126(25):2695-703
• All: 4 reference(s)