Dtnbp1^tm2.1Bcgen
Targeted Allele Detail

Summary

• Symbol: Dtnbp1^tm2.1Bcgen
• Name: dystrobrevin binding protein 1; targeted mutation 2.1, Biocytogen LLC
• MGI ID: MGI:5823067
• Synonyms: Dys1B⁺-myc
• Gene: Dtnbp1 Location: Chr13:45075552-45155614 bp, - strand Genetic Position: Chr13, 21.73 cM
• Alliance: Dtnbp1^tm2.1Bcgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238133
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 5; an FRT site flanked neomycin resistance gene cassette and the inverted cDNA for the human B isoform plus myc-tag sequence followed by an inverted splice acceptor site and an inverted loxP site were inserted into intron 6. Cre-mediated recombination inverted the sequence between the loxP sites and removed the selection cassette. RT-PCR confirmed expression of the transgene from this allele. (J:238133)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dtnbp1 Mutation: 26 strains or lines available

References

• Original: J:238133 Yang W, et al., The pathogenic mechanism of dysbindin-1B toxic aggregation: BLOC-1 and intercellular vesicle trafficking. Neuroscience. 2016 Oct 1;333:78-91
• All: 1 reference(s)