Dtnbp1^tm1.1Bcgen
Targeted Allele Detail

Summary

• Symbol: Dtnbp1^tm1.1Bcgen
• Name: dystrobrevin binding protein 1; targeted mutation 1.1, Biocytogen LLC
• MGI ID: MGI:5823066
• Synonyms: Dys1B⁺
• Gene: Dtnbp1 Location: Chr13:45075552-45155614 bp, - strand Genetic Position: Chr13, 21.73 cM
• Alliance: Dtnbp1^tm1.1Bcgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238133
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Modified isoform(s), Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 5; an FRT site flanked neomycin resistance gene cassette and the inverted cDNA for the human gene followed by an inverted splice acceptor site and an inverted loxP site were inserted into intron 6. Cre-mediated recombination inverted the sequence between the loxP sites and removed the selection cassette. RT-PCR confirmed expression of the transgene from this allele. (J:238133)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dtnbp1 Mutation: 26 strains or lines available

References

• Original: J:238133 Yang W, et al., The pathogenic mechanism of dysbindin-1B toxic aggregation: BLOC-1 and intercellular vesicle trafficking. Neuroscience. 2016 Oct 1;333:78-91
• All: 1 reference(s)