Pex1^tm1.2Sjms
Targeted Allele Detail

Summary

• Symbol: Pex1^tm1.2Sjms
• Name: peroxisomal biogenesis factor 1; targeted mutation 1.2, Steven Steinberg
• MGI ID: MGI:5822916
• Gene: Pex1 Location: Chr5:3646066-3687230 bp, + strand Genetic Position: Chr5, 2.26 cM, cytoband A2
• Alliance: Pex1^tm1.2Sjms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 x C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert a loxP site into intron 11, a loxP-FRT-flanked neomycin cassette into intron 13 and a G844D point mutation into exon 15. Flp-mediated recombination removed the FRT-flanked neo cassette. Cre-mediated recombination removed exons 12 and 13. (J:210296)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pex1 Mutation: 57 strains or lines available

References

• Original: J:210296 Hiebler S, et al., The Pex1-G844D mouse: a model for mild human Zellweger spectrum disorder. Mol Genet Metab. 2014 Apr;111(4):522-32
• All: 2 reference(s)