Tnik^tm1.1Alab
Targeted Allele Detail

Summary

• Symbol: Tnik^tm1.1Alab
• Name: TRAF2 and NCK interacting kinase; targeted mutation 1.1, Alain Burette
• MGI ID: MGI:5822840
• Synonyms: TNIK^delta7
• Gene: Tnik Location: Chr3:28317362-28724734 bp, + strand Genetic Position: Chr3, 11.92 cM
• Alliance: Tnik^tm1.1Alab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238171
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Through homologous recombination a loxP site was inserted into intron 6 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 7. Subsequent cre-mediated recombination deleted out-of-frame exon 7 (which encodes part of the kinase domain), thus creating a null allele with premature stop codons in exon 8. PCR confirmed the absence of exon 7 in transcripts from this allele. (J:238171)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnik Mutation: 80 strains or lines available

References

• Original: J:238171 Burette AC, et al., Organization of TNIK in dendritic spines. J Comp Neurol. 2015 Sep 01;523(13):1913-24
• All: 1 reference(s)